BIOPHARMWAT

Biofunctionalized interfaces as smart biosensors for fast identification of pharmaceutical and metabolites in waste waters

 

 

 


 

Abstract

Pharmaceuticals are a large, diverse group of organic compounds, which are very active at low concentrations and which are used in diagnosis, treatment or prevention of disease or other abnormal condition. There are growing public attention and concern about the possibility of ecosystem and human health effects from pharmaceuticals active ingredients and personal care products in water, comprising a diverse group of chemicals. Large amount of pharmaceuticals enter to environment through excretion after administration or disposal of unwanted medicamentation passing through the animal body to treatment plants which are not designed to remove them.The present proposal will be directed towards developing and validating new advanced biosensors for the rapid screening and quantification of the presence of undesirable pharmaceutical in waste waters. Novel design of the biosensors interface approaches will be investigated to detect these contaminants in real samples without matrix effects and for in situ measurements.


Contract: PN-II-ID-PCE-2011-3-0286, no. 195/2011

Acronym: BIOPHARMWAT

Contracting autority: UEFISCDI

Duration of the project: 36 months (2011-2014)

Project Director:

Prof. dr. Camelia Bala

University of Bucharest

Departament of Analytical Chemistry

Tel./Fax.: +40 21 4104888

email: camelia.bala@g.unibuc.ro

Team members:

Conf. dr. Lucian Rotariu

Drd. Zamfir Lucian-Gabriel

Drd. Istrate Oana-Maria


Reports

Fisier de tip .pdf ! Reports


Expected results:

  • Identification of the interaction type by kinetic studies.
  • Bioreceptor immobilization.
  • Study of the influence of operating conditions on the biosensor response.
  • Optimizing the performance response of the developed biosensors.

 

Dissemination

1. Sensors and Actuators B: Chemical, L.-G. Zamfir, L. Rotariu, V.E. Marinescu, X.T. Simelane, P.G.L. Baker, E.I. Iwuoha, C. Bala, 2016, 226, 525-533.

2. Microchimica Acta, O.-M. Istrate, L. Rotariu, Camelia Bala, 2016, 183(1), 57-65.

3. Sensors and Actuators B: Chemical, O.-M. Istrate, L. Rotariu, V. E. Marinescu, Camelia Bala, 2016, 223, 697-704.

4. Sensors and Actuators: B. Chemical, L.-G. Zamfir, L. Rotariu, Camelia Bala, 2015, 206, 65-73.

5. Biosensors and Bioelectronics,S. Azzouzi, L. Rotariu, A. M. Benito, W. K. Maser, M. Ben Ali, Camelia Bala, 2015, 69, 280-286.

6. Critical Reviews in Analytical Chemistry, Andreea Olaru, Camelia Bala, Nicole Jaffrezic-Renault, H. Y. Aboul-Enein, 2015, 45(2), 97-105.

7. Sensors & Actuators: B. Chemical, L.-G. Zamfir, L. Rotariu, Camelia Bala, 2015, 206, 65-73.

8. Chemical Communications, Mihaela Puiu, Andreea Idili, Danila Moscone, Francesco Ricci, Camelia Bala, 2014, 50 (64), 8962 – 8965

9. Biosensors and Bioelectronics, 46 (2013) 61–67, Lucian-Gabriel Zamfir, Lucian Rotariu, Camelia Bala.

10. Analytical Biochemistry, 421 (2012) 587–594, Mihaela Puiu, Oana Istrate, Lucian Rotariu, Camelia Bala.

11. Analytica Chimica Acta, 748 (2012) 81-88, Lucian Rotariu, Lucian-Gabriel Zamfir, Camelia Bala.

12. Sensors & Actuators: B. Chemical, Lucian Rotariu, Oana Istrate, Camelia Bala, 2014, 191, 491– 497.

13. New challenges in the design of bio(sensors) for biological warfare agents, Camelia Bala, in, Portable Chemical Sensors: Weapons Against Bioterrorism, D.P. Nikolelis (ed.), Springer Science-Business Media B.V., 2012, 15.

14.Water-soluble vitamins and drug residues determination, Andreea Olar, Camelia Bala, in Portable Biosensing of Food Toxicants and Environmental Pollutants, D. P. Nikolelis, T. Varzakas, A. Erdem, G.-P. Nikolelis (eds.), Taylor & Francis Group, Boca Raton, 2013, pag. 443-473.

15. XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society, 14-18 June, 2015, Malmö, Sweden, Carole Chaix, Camelia Bala, Nicole Jaffrezic-Renault (invited lecturer)

16. The Seventh International Workshop on Biosensors for Food Safety and Environmental Monitoring, Erfoud (Morocco), 19th to 21st November 2015, Camelia Bala (invited lecturer)

17. Regional Symposium on Elecrochemistry on South-East Europe, mai 2012, Bucharest, Romania, Lucian-Gabriel Zamfir, Lucian Rotariu, Camelia Bala (poster).

18. 22nd World Congress on Biosensors, 2012, Cancun, Mexic, Lucian-Gabriel Zamfir, Lucian Rotariu, Camelia Bala (oral presentation).

19. 244th ACS National Meeting, Session: New Directions in Electrochemical Analysis and Sensors, Philadelphia, Pennsylvania, 2012, Camelia Bala, Lucian-Gabriel Zamfir, Lucian Rotariu (oral presentation).

20. International Conference on Advanced Materials for Photonics, Sensing and Energy Conversion Applications, 2012, El Jadida, Marocco, Camelia Bala (invited lecture).

21. Workshop ‘’New trends in the research of carbon based nanomaterials’’, 2013, Bucharest, Romania, Camelia Bala (invited lecture).

22. Workshop on Bioinspired-nanotechology for Biosensing,Sitges, Spain, 2013, Lucian Rotariu, Lucian-Gabriel Zamfir, Camelia Bala (oral presentation). 

23. International Workshop “Recent Advances in Micro/Nano Sensors for Mono- and Multi-Target Assays”, Kiev, Ukraine, 2013, Camelia Bala (invited lecture). 

24. Fourth Regional Symposium of Electrochemistry of South East Europe, Ljubljana, Slovenia, 2013, Camelia Bala (invited lecture). 

25. Summer School ‘’Electrochemistry for Environmental and Biomedical Applications’’ Cluj-Napoca, Romania, 2013, Camelia Bala (plenary lecture).

26. Summer School ‘’Electrochemistry for Environmental and Biomedical Applications’’ Cluj-Napoca, Romania, 2013, Lucian-Gabriel Zamfir,  Lucian Rotariu, Camelia Bala (poster).

27. Summer School ‘’Electrochemistry for Environmental and Biomedical Applications’’ Cluj-Napoca, Romania, 2013, Oana Istrate, Lucian Rotariu, Camelia Bala (poster)

 

 

Last updated at: January 19, 2016.