Clinical Biochemistry

This course (20 h) is addressed to the students from Bachelor’s cycle (3rd year of study) – section of Biochemistry and approaches the next topics:  

1. Introduction in clinical pathology and applications of the medical biochemistry in the laboratory diagnostic.

2. Blood: Plasma and specialized cells; Anemias: macrocitic anemia (megaloblastic anemia, pernicious anemia), genetic hemolytic anemias: ereditary spherocytosis, ereditary elliptocytosis, deficiency in glucose-6-P-dehydrogenase, hemoglobinopathies (sickle cell anemia, thalassemias); Diseases associated to disturbances of iron metabolism (iron deficiency anemia, hemosiderosis, hemochromatosis).

3. Hepatic and biliary disorders: Biochemical tests of liver function; Hepatobiliary diseases: jaundice (hemolytic, hepatocellular and obstructive icterus), inherited disorders of bilirubin metabolism; Hepatitis; Hepatic fibrosis/cirrhosis.

4. Pancreas disorders: Acute and chronic pancreatitis,  cystic fibrosis (mucoviscidosis) pancreatic insuficiency; Diabetes mellitus (type I, II and gestational diabetes).

5. Renal patophysiology: Renal functions with clinical significance; Abnormal constituents of urine; Renal diseases: glomerular diseases (glomerulonephritis, nephrotic syndrome), tubular disorders of the kidney (renal tubular acidosis), urinary tract infections, urinary tract obstruction, kidney failure, diabetic nephropathy, renovascular hypertension. 

6. Heart pathophysiology: Miocardic enzymes with clinical significance; Heart disorders: ischemic heart disease, myocardial infarction, heart failure, cardiomiopathy, heart arrhythmias, valvular heart diseases.

7. Pathophysiology of artery diseases: Regulation of the vascular tonus, atherosclerosis, arterial hypertensions, arterial hypotension. 

 

 

 

 

 

 

 

Last updated at: June 21, 2016.