PCE-55-2017

Spaced TiO2 nanotubes as platforms for drug delivery and bone regeneration

Project leader:

Prof. Dr. Habil. Anisoara Cimpean

Phone number: 021.318.15.75/int 106

Fax: 021.318.15.75/int 102

E-mail: anisoara.cimpean@bio.unibuc.ro

Institution:University of Bucharest

Faculty of Biology

Department of Biochemistry and Molecular Biology, www.dbbm.bio.unibuc.ro

Project code: PN-III-P4-ID-PCE-2016-0691

Project type and number: PCE 55/2017

Project title: Spaced TiO2 nanotubes as platforms for drug delivery and bone regeneration

Acronym: NanoDelBone

Duration: 30 months

Budget: 850.000,00 lei

Research team: Fisier de tip .pdf ! PCE-55 team members 

Abstract:

In spite of the vast development and clinical use of titanium (Ti) based metallic implants and of their gold standard status for dental/orthopedic implants, in some cases Ti implants are encapsulated in vivo by fibrous tissue and show a lack of osseointegration which can finally lead to implant failure. To improve implant viability and its biologic performance, nanotechnology and local drug delivery strategies hold certain advantages through the modification of implants’ surface. In this context, the main objective of this project is to obtain novel platforms for bone regeneration and drug delivery applications. These platforms consist of spaced titania nanotubes modified Ti (TNT) with varying characteristics, loaded with simvastatin (with and without PLGA coating) as a model drug known to promote bone tissue formation. The goal of the project is to evaluate TNT as platforms for drug delivery and bone regeneration.

In depth research, data collection and analysis are envisaged in NanoDelBone project to test the hypothesis according to which drug loaded spaced TNT will improve the quality of life of people in need of bone implants, by a potentially faster recovery and reduced risk of failure or side-effects, due to poor osseointegration. If our expectation will be fulfilled, the findings may form a good foundation for further potential clinical validation of Ti-based implants with this innovative surface design as ready products for clinical applications.

The project is built on two pillars of expertise, namely the excellent capabilities in assessment of mammalian cell - biomaterial interactions at University of Bucharest, Faculty of Biology, and the outstanding background in the electrochemical deposition of TNT and their characterization at Friedrich Alexander University, which will provide the samples to be tested. To achieve the project goals, a research team with all of the requisite expertise has been formed.

The specific objectives of the project are:
  1. In vitro biological evaluation of spaced TNT;
  2. Establishing the optimal dose and drug release profile;
  3. Determination of spaced TNT efficacy as drug delivery vehicles through in vitro studies;
  4. Determination of the in vivo therapeutic efficacy of drug loaded spaced TNT.

The expected results of the project:

  • Acquiring new knowledge about the influence of spaced TNT on cells involved in bone regeneration;
  • In-depth understanding of the biological effects of newly developed materials on tissue-implant interactions;
  • Obtaining experimental and functional models;
  • Dissemination of project results through the web page to inform stakeholders about project progress;
  • Elaboration of Master theses (1) and PhD theses (1).

PUBLICATIONS

Last updated at: October 24, 2017.