Developmental molecular biology

 

The course analyzes the molecular mechanisms that underlie the development of organisms. Specific topics include:

  • Molecular mechanism of cell determination and differentiation: genomic equivalence and vertebrate cloning; mechanisms of cell specification (autonomous, syncytial, conditional); transdifferentiation and dedifferentiation. 
  • Transcriptional regulation in embryogenesis: zinc finger transcription factors (C2H2, nuclear receptors, LIM, GATA); leucin zipper transcription factor; HLH transcription factors; HTH transcription factors (homeodomain proteins, PAX, FOX, ETS); REL transcription factor; MADS-Box transcription factors; HMG proteins; T-Box transcription factor; nuclear architecture and epigenetic regulation: chromatin remodeling proteins (Polycomb and Trithorax groups of proteins), DNA methylation and genomic imprinting. 
  • Post-transcriptional regulation in embryogenesis: RNA localization and translation in development; mechanisms of mRNA localization. 
  • Molecular control of embryonic pattern formation: molecular mechanisms of anterior-posterior axis specification in Drosophila: maternal effect genes, segmentation genes (gap genes, pair-rule genes and segment polarity genes), homeotic selector genes; mammalian anterior-posterior axis formation and expression of Hox genes. 
  • Embryonic signal transduction pathways: WNT, BMP, Hedgehog, Notch-Delta.

 

 

 

 

 

 

 

Last updated at: February 04, 2017.